Our Research Focus


Synthetic chemistry has the power to enable far-reaching investigations into human biology. Research in the Spiegel lab focuses on organic synthesis, with a specific emphasis on developing new methods and molecules that will facilitate our understanding and treatment of human disease. Ongoing projects range from synthetic reaction development and natural product synthesis to the construction of functional molecules capable of accomplishing specific biological tasks.



october 2015

Cristian and Tina’s paper on the synthesis of glucosepane is now published in Science! Read about it here.


september 2015

Click here to see David on 'SciTech Now', discussing our fascinating work on synthetic immunology.


august 2015

We are excited to announce that Allied-Bristol Life Sciences (ABLS) has licensed our immuno-oncology platform and lead molecules known as Antibody-Recruiting Molecules (ARMs).

august 2015

Congratulations to David - a recipient of the 2016 Arthur C. Cope Scholar Awards in recognition of excellence in organic chemistry.

JULY 2015

See Tina and Matt’s paper "Generation and Characterization of Antibodies Against Arginine-derived Advanced Glycation End Products” in Bioorganic & Medicinal Chemistry Letters.

June 2015

Samir and Phil's paper, "Chemical Probes Reveal an Extraseptal Mode of Cross-Linking in Staphylococcus aureus” is now published in JACS. Check it out here!

MAY 2015

Matt Streeter passes his 2nd Year Qualifying Exam...way to go, Matt!



MAY 2015

Group alum, Eugene Douglass, has received the renowned NAGS Dissertation Award! His dissertation on “Understanding Drugs That Bind Multiple Targets” was recognized by the Northeastern Association of Graduate Schools as the outstanding dissertation of 2014-2015.

MAY 2015

Kelly Fitzgerald has successfully defending her dissertation entitled “Small Molecule Immunomodulators as Cancer Therapeutics”. Congratulations, Dr. Fitzgerald!

APRIL 2015

Congrats to Jaylissa and Sarah on getting their NSF grant applications funded - marvelous work, ladies!


February 2015

Congratulations to Tina for successfully defending her thesis entitled "Chemical Perspectives on Protein Glycation" - excellent work, Dr. Wang!

February 2015

See highlights of the lab’s recent article, reporting the first synthetic molecules that possess both the targeting and effector functions of antibodies, in the following publications: Nature News & Views, Scientific American, and C&E News.  

January 2015

The Spiegel Lab is excited to announce its newest graduate students: Sarah Malkowski, Joseph Piechocki, Jaylissa Torres, and Mengwen (Clarice) Zheng. Welcome!


Congratulations to Patrick and Kelly on their paper entitled "Chemically Synthesized Molecules with the Targeting and Effector Functions of Antibodies", now published online and as ASAP in JACS. Great work!

MAY 2014

Congratulations to David on his promotion to full Professor at Yale!



APRIL 2014

Check out Chris and Nancy’s paper “Illuminating HIV-1 gp120­Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules" in Chemical Science.


Congratulations to Phil on his work on developing a liver-targeting mitochondrial uncoupler that can serve as a potential therapeutic agent for hypertriglyceridemia, non-alcoholic fatty liver disease, and insulin resistance, in collaboration with the Shulman Group at Yale. Read about it here: Cell Metabolism


Thihan & Patrick's chapter on Synthetic Immunology is published in the book "Biotherapeutics: Recent Developments using Chemical and Molecular Biology". View the abstract.


Chuck’s paper identifying immune effector functions of natural human antibodies against various synthetic antibody recruiting molecules is now published in ACS Chemical Biology. Well done, Professor Jakobsche!


Check out Tina's recent JACS paper highlighting the development of a “turn-on” fluorescent sensor selective for methylglyoxal. Also featured in this week's C&EN! Nice job, Tina!

June 2013

Congratulations to Phil on his publication in Tetrahedron, which highlights the serendipitous discovery of two highly selective inhibitors of bacterial luciferase. Great work, Phil!

APRIL 2013

Eugene's paper is accepted to JACS!
This publication provides a comprehensive mathematical framework for understanding ternary complex equilibria, previously believed to be analytically intractable. Find it here.

APRIL 2013

Congratulations to Samir and Phil on their recent review article in Trends in Biotechnology. The article highlights strategies to functionalize bacterial surfaces with small molecules and the applications of these strategies in biotechnology and biomedicine. Check it out!

December 2012

David is awarded $3.6 million as a Department of Defense Era of Hope Scholar Award recipient. This will fund research for the development of a novel technology platform for developing personalized therapeutics for breast cancer. More about this exciting accomplishment can be found in the Yale News.


Congratulations to Phil Kim on the acceptance of his manuscript disclosing the unique reactivity of N-phenacyl-derived thiazolium salts toward alpha-dicarbonyl compounds. Check it out in Rejuvenation Research...well done, Phil!


Andrew Zhang becomes the inaugural Spiegel Group member to defend his thesis. Congratulations Dr. Zhang!



See David's live UStream press conference on ARMs research during the Philadelphia National ACS Meeting. This research was also highlighted on About.com Pharma Guide.

JULY 2012

A big welcome to Mia Huang, the group's newest Postdoctoral Associate, who comes to us from Kent Kirshenbaum 's lab at NYU!


JULY 2012

The group's review on antibody-recruiting molecules is published in ACS Chemical Biology. Congratulations Pat, Chris, and Andrew!

JUNE 2012

David is the host of a Synthetic Immunology Ask the Expert forum on the ACS Chemical Biology community website. Post a question, thought, or comment here: Ask the Expert

APRIL 2012

The group reports their research into post-translational arginine modifications in JACS.
Congratulations to Tina and Prof. Rendy Kartika!

March, 2011

Watch David's Advanced Glycation End-products presentation at the SENS-5 Conference in Cambridge, England.



We proudly announce that David has been awarded a Novartis Early Career Award in Organic Chemistry for outstanding research within 10 years of starting his independent career. Congratulations, David! Read more about the Novartis Award.


The group reports an anti-cancer strategy utilizing antibody-recruiting molecules to target urokinase receptors. Congratulations to Chuck, Pat, and Andrew!


Congratulations to Chad Miller and Kelly Fitzgerald on passing their Pharmacology qualifying exams!



We are pleased to welcome Postdoctoral Associate Cristian Draghici, who comes to us from the lab of Jon Njardarson at Arizona.

JULY, 2011

Congratulations to Chuck Jakobsche who was recently awarded a prestigious NIH Ruth Kirschstein postdoctoral fellowship through the National Cancer Institute.

May, 2011

The Spiegel Group welcomes newest members Samir Gautam, Chad Miller and Julian Vastl.



Congratulations to David for being named one of this year's recipients of the Alfred P. Sloan Foundation Research Fellowship!
Sloan Foundation, New Haven Register, NY Times

February, 2011

A highlight of the lab's work on antibody-recruiting molecules is published in the Yale Scientific Magazine. Congratulations!


The Spiegel Group is pleased to welcome newest group members, graduate students Nancy Tao and Kelly Fitzgerald, and laboratory associate, Dr. Takuji Shoda.


Congratulations to David for being selected as one of the winners of this year's Nature Chemical Biology Grand Challenges Essay Contest.  His essay, entitled "Synthetic Immunology to engineer human immunity" is currently available online in the 5th anniversary issue of Nature Chemical Biology.  


Our article in ACS Chemical Biology about re-engineering the Staphylococcus aureus cell wall with non-native small molecules has been highlighted in Cell, Biotechniques, R&D Magazine, Science Daily, Infection Research, e! Science News and Yale Daily News!


Our strategy for biosynthetically incorporating small molecules into the Staphylococcus aureus cell wall is published in ACS Chemical Biology.

september, 2010

Our recent article about the discovery of a novel arene binding site on
prostate specific membrane antigen by ARM-Ps has been highlighted in C&E News
and Nature Chemical Biology!

august, 2010

The group reports investigations into antibody-recruiting small molecules targeting prostate cancer (ARM-Ps) in JACS. These studies describe the discovery of a novel arene binding site on prostate specific membrane antigen, the target of ARM-Ps. Congratulations Andrew!  

June, 2010

Congratulations to group members Phil Kim and Eugene Douglass for passing their oral exams!

APRIL, 2010

The lab's work on antibody-recruiting molecules targeting prostate
cancer has been highlighted in ChemBioChem!

MARCH, 2010

Congratulations to Jason Gandelman, a senior at Staples High School, for being named one the 40 finalists in the Intel Science Talent Search!  Jason has been working on a project related to the formation of advanced glycation end-products in the lab and has made great progress.  Go Jason!

March, 2010

We are pleased to announce recent press coverage of antibody-recruiting small molecules targeting HIV and prostate cancer. This work has been highlighted in numerous publications and websites including Drug Discovery News, Popular Science, R&D Magazine, e! Science News, Science Daily, Genetic Engineering & Biotechnology News, and ACS Noteworthy Chemistry.

MARCH, 2010

The Spiegel Group is pleased to welcome their newest member, graduate student Tina Wang.

February, 2010

The lab's recent article involving antibody-recruiting small molecules targeting prostate cancer is reviewed as a "must read" paper on the Faculty of 1000, and is ranked among the top 10 "hidden jewels" and most read papers in the field of chemical biology. REVIEW

January, 2010

Recent Spiegel group publications on Antibody-Recruiting have been spotlighted in ACS Chemical Biology.  Congratulations to Andrew, Chris, and Ryan! SPOTLIGHT


The group reports a novel strategy for recruiting endogenous antibodies to prostate cancer cells. Congratulations to Ryan and Andrew! JACS


The group reports a novel small-molecule-based strategy for enhancing immune recognition of HIV. Congratulations to Chris Parker! JACS


Welcome to new postdoctoral researcher Chuck Jakobsche, coming from Scott Miller's group at Yale, and visiting researcher Alex Chamessian from Stony Brook University.

APRIL, 2009

David Spiegel has received a Bill & Melinda Gates Foundation Grand Challenges Explorations award for innovation in global health research .

January, 2009

The Spiegel Group welcomes new graduate student group members Eugene Douglass, Taehan (Phil) Kim and Maria Noy.


The Spiegel Group welcomes postdoctoral researcher Rendy Kartika, coming from

Richard E. Taylor's group at University of

Notre Dame.


Congratulations David on being named one of this year’s recipients of the Ellison Medical Foundation New Scholar Award!

July, 2008

Welcome to postdoctoral researcher Mariya

Kolesnikova, who comes to us from Seiichi

Matsuda's group at Rice University.

September, 2007

David Spiegel was recently named one of the first recipients of the NIH Director’s New Innovator Award.

January 7, 2008

Read an article about research in the Spiegel Lab in the Yale Daily News.


March, 2008

Welcome to new group members Chris Parker, Alison Wendlandt, Andrew Zhang, James Nelson, and Patrick McEnaney!