The Spiegel Lab focuses on developing new synthetic approaches that will help enable our understanding and treatment of human disease. Ongoing project areas of interest to the group include: (1) The development of synthetic molecules capable of refocusing the human immune system towards diseased or infected tissues. Such methods could represent entirely novel treatment modalities, which we hope will prove quite general with respect to target. (2) Total syntheses of complex natural products. Particular emphasis here will be placed upon natural products found in humans with unknown roles in normal and disease physiology. Synthetic access to these materials will allow us to elucidate disease pathways, with an eye toward therapeutics development. New chemical reactions will be developed as a means of complementing these synthetic sequences.